Institute: Institute for Science and Technology in Medicine, School of Pharmacy, Keele University
I gained degrees in Computer Science and Biochemistry/Neuroscience before completing a Biomedical Engineering PhD at Keele University (2013). During my PhD I developed in vitro neural culture systems to test nanoparticle-based tissue engineering of neural cell transplant populations. This encompassed genetic engineering and cell tracking applications, to promote regeneration in the brain and spinal cord.
During my PhD, I was awarded an E-TERM Landscape Fellowship by EPSRC, to test novel magnetic devices, designed by an industrial partner to enhance the utility of magnetic nanoparticles for cellular engineering. My research has highlighted the importance of the neuroimmunological component of the brain: microglia. I am currently investigating methods to evade these cells (e.g. for nanomedicine delivery), or harness their restorative potential by controlling microglial phenotype/activation to promote regeneration through immunomodulation.
Developing regenerative therapies for the brain and spinal cord, by designing in vitro disease/injury testbeds for tissue engineering approaches.
In vitro models of neurodegenerative disease/injury
Time-lapse microscopy, live imaging of 3D cultures (hydrogels, organotypic slices)
Tissue engineering: Nanoparticles for genetic engineering and cell tracking
Molecular biology (RT-qPCR)