Tissue Engineering and Cell Therapies
Cellular engineering using techniques such as genome editing, CRISPR, and directed differentiation presents an attractive strategy to develop personalised and generic cell based TERM therapeutics. A current limitation of these therapies is a lack of understanding with regards to controlling the behaviour of these cells post-manipulation. For cell therapies to be widely adopted, and reimbursable, methods need to be developed to asses cellular behaviour post implantation.
Issues associated with differentiation, de-differentiation and trans-differentiation of cell products, clinical cell source phenotyping and cellular manufacturing will be addressed to allow for the identification of new goals that will enable us to harness cellular behaviour for therapeutic use.