Professor Matthew Dalby
Nanoscale approaches to control mesenchymal stem cell growth and differentiation
Mesenchymal stem cells are highly responsive to nanoscale cues. This talk will focus on the use of nano topography, nano fibrous hydrogels and nanoscale vibrational stimulation (nanokicking) in the control of MSC self-renewal (to deliver large amounts of high quality stem cells) and differentiation (for regenerative therapies). Further, the use of polymer scaffolds that provide growth factors to cells at ultra-low dose but with high biological efficiency will be discussed. Throughout mechanotransductive pathways will be considered.
Prof. Dalby obtained his PhD in Biomedical Materials from Queen Mary, University of London on osteoblast response to the topography and composition of hydroxyapatite containing composite materials. He then joined Glasgow University as a PDRA to work in Cell Engineering. Here he researched how cells interact with nanoscale features producing early literature on cellular ability to respond to nanotopography. His interests in bone, nanotopography and mechanotransduction led to securing a BBSRC David Phillips Fellowship in 2003. During this fellowship his work on how mesenchymal stem cells were directed to differentiate or self-renew by nanotopography led to a lectureship in Cell Engineering in 2008. Now, as Professor of Cell Engineering, he remains fascinated by the nanoscale and mechanotransductive processes, but his interests have broadened to include metabolomics-based research and a growing interest in how growth factors can be controlled at the nanoscale to direct stem cell fate.